Ontology highlight
ABSTRACT:
SUBMITTER: Du H
PROVIDER: S-EPMC10320204 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Du Hekang H Xiao Nanyang N Zhang Sitong S Zhou Xueyuan X Zhang Yangfan Y Lu Zengzeng Z Fu Yuqian Y Huang Miaohui M Xu Shan S Chen Qi Q
iScience 20230610 7
TREX1 encodes a major DNA exonuclease and mutations of this gene are associated with type I interferonopathies in human. Mice with <i>Trex1</i> deletion or mutation have shortened life spans accompanied by a senescence-associated secretory phenotype. However, the contribution of cellular senescence in <i>TREX1</i> deficiency-induced type I interferonopathies remains unknown. We found that features of cellular senescence present in <i>Trex1</i><sup><i>-/-</i></sup> mice are induced by multiple fa ...[more]