Ontology highlight
ABSTRACT:
SUBMITTER: Metcalf MC
PROVIDER: S-EPMC10322937 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Metcalf Matthew C MC Janus Benjamin M BM Yin Rui R Wang Ruixue R Guest Johnathan D JD Pozharski Edwin E Law Mansun M Mariuzza Roy A RA Toth Eric A EA Pierce Brian G BG Fuerst Thomas R TR Ofek Gilad G
Nature communications 20230705 1
Hepatitis C virus (HCV) is a major global health burden as the leading causative agent of chronic liver disease and hepatocellular carcinoma. While the main antigenic target for HCV-neutralizing antibodies is the membrane-associated E1E2 surface glycoprotein, the development of effective vaccines has been hindered by complications in the biochemical preparation of soluble E1E2 ectodomains. Here, we present a cryo-EM structure of an engineered, secreted E1E2 ectodomain of genotype 1b in complex w ...[more]