Ontology highlight
ABSTRACT:
SUBMITTER: de Jong YP
PROVIDER: S-EPMC4312107 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
de Jong Ype P YP Dorner Marcus M Mommersteeg Michiel C MC Xiao Jing W JW Balazs Alejandro B AB Robbins Justin B JB Winer Benjamin Y BY Gerges Sherif S Vega Kevin K Labitt Rachael N RN Donovan Bridget M BM Giang Erick E Krishnan Anuradha A Chiriboga Luis L Charlton Michael R MR Burton Dennis R DR Baltimore David D Law Mansun M Rice Charles M CM Ploss Alexander A
Science translational medicine 20140901 254
In most exposed individuals, hepatitis C virus (HCV) establishes a chronic infection; this long-term infection in turn contributes to the development of liver diseases such as cirrhosis and hepatocellular carcinoma. The role of antibodies directed against HCV in disease progression is poorly understood. Neutralizing antibodies (nAbs) can prevent HCV infection in vitro and in animal models. However, the effects of nAbs on an established HCV infection are unclear. We demonstrate that three broadly ...[more]