Ontology highlight
ABSTRACT:
SUBMITTER: Bulte D
PROVIDER: S-EPMC10340308 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Bulté Dimitri D Rigamonti Chiara C Romano Alessandro A Mortellaro Alessandra A
Cells 20230703 13
Inflammasome complexes and their integral receptor proteins have essential roles in regulating the innate immune response and inflammation at the post-translational level. Yet despite their protective role, aberrant activation of inflammasome proteins and gain of function mutations in inflammasome component genes seem to contribute to the development and progression of human autoimmune and autoinflammatory diseases. In the past decade, our understanding of inflammasome biology and activation mec ...[more]