The effects of two cytotoxic gold(i) carbene compounds on the metabolism of A2780 ovarian cancer cells: mechanistic inferences through NMR analysis.
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ABSTRACT:
SUBMITTER: Ghini V
PROVIDER: S-EPMC10354608 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
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The effects of two cytotoxic gold(i) carbene compounds on the metabolism of A2780 ovarian cancer cells: mechanistic inferences through NMR analysis.
Ghini Veronica V Mannelli Michele M Massai Lara L Geri Andrea A Zineddu Stefano S Gamberi Tania T Messori Luigi L Turano Paola P
RSC advances 20230719 31
NMR metabolomics is a powerful tool to characterise the changes in cancer cell metabolism elicited by anticancer drugs. Here, the large metabolic alterations produced by two cytotoxic gold carbene compounds in A2780 ovarian cancer cells are described and discussed in comparison to auranofin, in the frame of the available mechanistic knowledge. ...[more]
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