Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Author Correction: Single-cell transcriptomics identifies Mcl-1 as a target for senolytic therapy in cancer.

ABSTRACT:

SUBMITTER: Troiani M

PROVIDER: S-EPMC10359282 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Publications

Author Correction: Single-cell transcriptomics identifies Mcl-1 as a target for senolytic therapy in cancer.

Troiani Martina M Colucci Manuel M D'Ambrosio Mariantonietta M Guccini Ilaria I Pasquini Emiliano E Varesi Angelica A Valdata Aurora A Mosole Simone S Revandkar Ajinkya A Attanasio Giuseppe G Rinaldi Andrea A Rinaldi Anna A Bolis Marco M Cippà Pietro P Alimonti Andrea A

Nature communications 20230720 1

PMID: 37474528

Similar Datasets

Single-cell transcriptomics identifies Mcl-1 as a target for senolytic therapy in cancer.

Project description:Cells subjected to treatment with anti-cancer therapies can evade apoptosis through cellular senescence. Persistent senescent tumor cells remain metabolically active, possess a secretory phenotype, and can promote tumor proliferation and metastatic dissemination. Removal of senescent tumor cells (senolytic therapy) has therefore emerged as a promising therapeutic strategy. Here, using single-cell RNA-sequencing, we find that senescent tumor cells rely on the anti-apoptotic gene Mcl-1 for their survival. Mcl-1 is upregulated in senescent tumor cells, including cells expressing low levels of Bcl-2, an established target for senolytic therapy. While treatment with the Bcl-2 inhibitor Navitoclax results in the reduction of metastases in tumor bearing mice, treatment with the Mcl-1 inhibitor S63845 leads to complete elimination of senescent tumor cells and metastases. These findings provide insights on the mechanism by which senescent tumor cells survive and reveal a vulnerability that can be exploited for cancer therapy.

| S-EPMC9023465 | biostudies-literature

Author Correction: Single-cell brain organoid screening identifies developmental defects in autism.