Ontology highlight
ABSTRACT:
SUBMITTER: Wang D
PROVIDER: S-EPMC10362062 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Nature communications 20230721 1
Histone H4 lysine 16 acetylation (H4K16ac), governed by the histone acetyltransferase MOF, orchestrates gene expression regulation and chromatin interaction. However, the roles of MOF and H4K16ac in controlling cellular function and regulating mammalian tissue development remain unclear. Here we show that conditional deletion of Mof in the skin, but not Kansl1, causes severe defects in the self-renewal of basal epithelial progenitors, epidermal differentiation, and hair follicle growth, resultin ...[more]