Ontology highlight
ABSTRACT:
SUBMITTER: Sharma GG
PROVIDER: S-EPMC2897562 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Sharma Girdhar G GG So Sairei S Gupta Arun A Kumar Rakesh R Cayrou Christelle C Avvakumov Nikita N Bhadra Utpal U Pandita Raj K RK Porteus Matthew H MH Chen David J DJ Cote Jacques J Pandita Tej K TK
Molecular and cellular biology 20100517 14
The human MOF gene encodes a protein that specifically acetylates histone H4 at lysine 16 (H4K16ac). Here we show that reduced levels of H4K16ac correlate with a defective DNA damage response (DDR) and double-strand break (DSB) repair to ionizing radiation (IR). The defect, however, is not due to altered expression of proteins involved in DDR. Abrogation of IR-induced DDR by MOF depletion is inhibited by blocking H4K16ac deacetylation. MOF was found to be associated with the DNA-dependent protei ...[more]