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Detection and sequence analysis of hepatitis B virus integration in peripheral blood mononuclear cells.

ABSTRACT: A PCR-based technique was used to detect hepatitis B virus (HBV) integration in peripheral blood mononuclear cells from patients with chronic hepatitis B. Integrated HBV DNA sequences, with virus-cell junctions located in the cohesive region between direct repeat 1 (DR1) and DR2, were found in 2 of 10 studied patients.

SUBMITTER: Laskus T 

PROVIDER: S-EPMC103945 | biostudies-literature | 1999 Feb

REPOSITORIES: biostudies-literature

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Detection and sequence analysis of hepatitis B virus integration in peripheral blood mononuclear cells.

Laskus T T   Radkowski M M   Wang L F LF   Nowicki M M   Rakela J J  

Journal of virology 19990201 2

A PCR-based technique was used to detect hepatitis B virus (HBV) integration in peripheral blood mononuclear cells from patients with chronic hepatitis B. Integrated HBV DNA sequences, with virus-cell junctions located in the cohesive region between direct repeat 1 (DR1) and DR2, were found in 2 of 10 studied patients. ...[more]

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