Dataset Information

Polymorphism of LRP4 Gene (rs9667108) among Post Menopause Women with Osteoporosis.

ABSTRACT:

Background

Many studies have been done to identify the factors that influence the development and progression of osteoporosis. One genetic factor is polymorphisms of LRP4 gene. Regarding the lack of comprehensive study on polymorphisms of LRP4 gene in the north of Iran, mainly Mazandaran Province, we decided to investigate the polymorphism of this gene in postmenopausal women with osteoporosis.

Methods

This case-control study has been conducted at GhaemShahr Valiasr Hospital on 100 female patients with osteoporosis (average age of 58.1) and 90 healthy females without osteoporosis (average age of 55.2). After sampling and extraction of genomic DNA via of the salt deposition method, the genotype and SNP (rs9667108) polymorphism of LRP4 gene were evaluated with the PCR-RFLP method. Restriction enzymes cut the PCR products. In order to identify patients, their bone mineral density was tested by the DEXA method. The results of digestion (digestion enzyme) were analyzed by MedCalc, SPSS software, Hardy-Weinberg equilibrium, and Chi2.

Results

The statistical analysis has shown the significant relationship between SNP (rs9667108) polymorphism and the risk of osteoporosis disease in patients and control groups (P<0.05). In SNP (rs9667108), the GC genotype, compared to GG, increased the risk of disease significantly (1.556 time). Similarly, CC genotype, compared to GG genotype, increased the risk of this disease by 2.091 time.

Conclusion

The existence of mutation in the LRP4 gene could increase susceptibility to osteoporosis disease. Moreover, determining this patient's genotype in SNP (rs9667108) can be used to identify individuals who are in endanger osteoporosis.

SUBMITTER: Kavoosian S

PROVIDER: S-EPMC10404332 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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Publications

Polymorphism of LRP4 Gene (rs9667108) among Post Menopause Women with Osteoporosis.

Kavoosian Saeid S Asgharian Alimohammad A Asouri Mohsen M Fattahi Sadegh S Amirbozorgi Galia G Kheirandish Ali A Abolfazli Sajad S Lotfi Maryam M Ebrahimi Nima N Ataee Ramin R

Iranian journal of public health 20230401 4

<h4>Background</h4>Many studies have been done to identify the factors that influence the development and progression of osteoporosis. One genetic factor is polymorphisms of <i>LRP4</i> gene. Regarding the lack of comprehensive study on polymorphisms of <i>LRP4</i> gene in the north of Iran, mainly Mazandaran Province, we decided to investigate the polymorphism of this gene in postmenopausal women with osteoporosis.<h4>Methods</h4>This case-control study has been conducted at GhaemShahr Valiasr ...[more]

PMID: 37551184

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Project description:BackgroundAdherence to anti-osteoporosis treatments is poor, exposing treated women to increased fracture risk. Determinants of poor adherence are poorly understood. The study aims to determine physician- and patient- rated treatment compliance with osteoporosis treatments and to evaluate factors influencing compliance.MethodsThis was an observational, cross-sectional pharmacoepidemiological study with a randomly-selected sample of 420 GPs, 154 rheumatologists and 110 gynaecologists practicing in France. Investigators included post-menopausal women with a diagnosis of osteoporosis and a treatment initiated in the previous six months. Investigators completed a questionnaire on clinical features, treatments and medical history, and on patient compliance. Patients completed a questionnaire on sociodemographic features, lifestyle, attitudes and knowledge about osteoporosis, treatment compliance, treatment satisfaction and quality of life. Treatment compliance was evaluated with the Morisky Medication-taking Adherence Scale. Variables collected in the questionnaires were evaluated for association with compliance using multivariate logistic regression analysis.Results785 women were evaluated. Physicians considered 95.4% of the sample to be compliant, but only 65.5% of women considered themselves compliant. The correlation between patient and physician perceptions of compliance was low (?: 0.11 [95% CI: 0.06 to 0.16]). Patient-rated compliance was highest for monthly bisphosphonates (79.7%) and lowest for hormone substitution therapy (50.0%). Six variables were associated with compliance: treatment administration frequency, perceptions of long-term treatment acceptability, perceptions of health consequences of osteoporosis, perceptions of knowledge about osteoporosis, exercise and mental quality of life.ConclusionCompliance to anti-osteoporosis treatments is poor. Reduction of dosing regimen frequency and patient education may be useful ways of improving compliance.

Dataset Information

Polymorphism of LRP4 Gene (rs9667108) among Post Menopause Women with Osteoporosis.

Background

Methods

Results

Conclusion

Publications

Polymorphism of LRP4 Gene (rs9667108) among Post Menopause Women with Osteoporosis.

Similar Datasets

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