Dataset Information

Association between osteoporosis and menopause in relation to SOX6 rs297325 variant in Taiwanese women.

ABSTRACT: OBJECTIVE:Osteoporosis, the most prevalent bone disorder in humans, is a global public health issue and its relationship with menopause is well-established. The interaction between menopause and genes on osteoporosis risk is, however, yet to be fully elucidated. We assessed the association between menopause and osteoporosis in relation to the SOX6 rs297325 variant in Taiwanese women. METHODS:There were 7,581 female participants, aged 30 to 70 years old. Information on SOX6 rs297325 and menopause were obtained from the Taiwan Biobank Database while that on osteoporosis was obtained from the National Health Insurance Research Database. RESULTS:Menopause but not SOX6 rs297325 was significantly associated with a higher risk of osteoporosis (odds ratio [OR]?=?1.48; 95% confidence interval [CI]?=?1.04-2.10). The interaction between menopause and rs297325 on osteoporosis was significant (P?=?0.0216). After stratification by rs297325 genotypes, the risk of osteoporosis was significantly higher in menopausal women having the TT?+?CC genotype (OR?=?2.02; 95% CI?=?1.21-3.38). After stratification by menopausal status and rs297325 genotypes, the OR; 95% CI was 0.62; 0.38 to 0.99 in premenopausal women with the TC?+?CC genotype and 1.24; 0.82 to 1.88 in menopausal women with the TC?+?CC genotype. CONCLUSION:SOX6 rs297325 was not significantly associated with osteoporosis but might have modulated the association between menopause and osteoporosis. The risk of osteoporosis was higher in menopausal women with the TC?+?CC genotype but lower in premenopausal women with the TC?+?CC genotype.

SUBMITTER: Hsu TL

PROVIDER: S-EPMC7386873 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Association between osteoporosis and menopause in relation to SOX6 rs297325 variant in Taiwanese women.

Hsu Tzu-Liang TL Tantoh Disline Manli DM Chou Ying-Hsiang YH Hsu Shu-Yi SY Ho Chien-Chang CC Lung Chia-Chi CC Jan Cheng-Feng CF Wang Lee L Liaw Yung-Po YP

Menopause (New York, N.Y.) 20200801 8

<h4>Objective</h4>Osteoporosis, the most prevalent bone disorder in humans, is a global public health issue and its relationship with menopause is well-established. The interaction between menopause and genes on osteoporosis risk is, however, yet to be fully elucidated. We assessed the association between menopause and osteoporosis in relation to the SOX6 rs297325 variant in Taiwanese women.<h4>Methods</h4>There were 7,581 female participants, aged 30 to 70 years old. Information on SOX6 rs29732 ...[more]

PMID: 32187136

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Project description:Growing evidence suggests that the gut microbiota and their metabolites are associated with bone homeostasis and fragility. However, this association is limited to microbial taxonomic differences. This study aimed to explore whether gut bacterial community associations, composition, and functions are associated with osteopenia and osteoporosis. We compared the gut bacterial community composition and interactions of healthy postmenopausal women with normal bone density (n = 8) with those of postmenopausal women with osteopenia (n = 18) and osteoporosis (n = 21) through 16S rRNA sequencing coupled with network biology and statistical analyses. The results of this study showed reduced alpha diversity in patients with osteoporosis, followed by that in patients with osteopenia, then in healthy controls. Taxonomic analysis revealed that significantly enriched bacterial genera with higher abundance was observed in patients with osteoporosis and osteopenia than in healthy subjects. Additionally, a co-occurrence network revealed that, compared to healthy controls, bacterial interactions were higher in patients with osteoporosis, followed by those with osteopenia. Further, NetShift analysis showed that a higher number of bacteria drove changes in the microbial community structure of patients with osteoporosis than osteopenia. Correlation analysis revealed that most of these driver bacteria had a significant positive relationship with several significant metabolic pathways. Further, ordination analysis revealed that height and T-score were the primary variables influencing the gut microbial community structure. Taken together, this study evaluated that microbial community interaction is more important than the taxonomic differences in knowing the critical role of gut microbiota in postmenopausal women associated with osteopenia and osteoporosis. Additionally, the significantly enriched bacteria and functional pathways might be potential biomarkers for the prognosis and treatment of postmenopausal women with osteopenia and osteoporosis.

Dataset Information

Association between osteoporosis and menopause in relation to SOX6 rs297325 variant in Taiwanese women.

Publications

Association between osteoporosis and menopause in relation to SOX6 rs297325 variant in Taiwanese women.

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