Ontology highlight
ABSTRACT:
SUBMITTER: Iskandar SE
PROVIDER: S-EPMC10411329 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Iskandar Sabrina E SE Pelton Jarrett M JM Wick Elizaveta T ET Bolhuis Derek L DL Baldwin Albert S AS Emanuele Michael J MJ Brown Nicholas G NG Bowers Albert A AA
Journal of the American Chemical Society 20230111 3
mRNA display is revolutionizing peptide drug discovery through its ability to quickly identify potent peptide binders of therapeutic protein targets. Methods to expand the chemical diversity of display libraries are continually needed to increase the likelihood of identifying clinically relevant peptide ligands. Orthogonal aminoacyl-tRNA synthetases (ORSs) have proven utility in cellular genetic code expansion, but are relatively underexplored for <i>in vitro</i> translation (IVT) and mRNA displ ...[more]