Dataset Information

The association between serum adipokines levels with senile osteoporosis: a systematic review and meta-analysis.

ABSTRACT:

Objective

The clinical correlation between adipokines levels in the blood and the incidence of senile osteoporosis (SOP) has not been clearly studied. We conducted this meta-analysis to elucidate the relationship between three common adipokines levels (leptin, adiponectin, and chemerin) and the incidence of SOP.

Methods

We searched databases such as CNKI, CBM, VIP, Wanfang, PubMed, Web of Science, Embase, and the Cochrane Library to collect articles published since the establishment of the database until July 30, 2022.

Results

In total, 11 studies met the selection criteria. Our meta-analysis showed that serum leptin levels were significantly lower (mean difference [MD], -2.53, 95% CI: -3.96 to -1.10, I² = 96%), chemerin levels were significantly higher (MD, 30.06, 95% CI: 16.71 to 43.40, I² = 94%), and adiponectin levels were not significantly different (MD, -0.55, 95% CI: -2.26 to 1.17, P = 0.53, I² = 98%) in SOP patients compared with healthy older individuals with normal bone mineral density (BMD). In addition, correlation analysis showed that leptin levels were positively correlated with lumbar bone mineral density (LBMD) (r = 0.36) and femoral bone mineral density (FBMD) (r = 0.38), chemerin levels were negatively correlated with LBMD (r = -0.55) and FBMD (r = -0.48), and there were significant positive correlations between leptin and adiponectin levels and body mass index (BMI) (r = 0.91 and 0.97).

Conclusions

The likelihood of having SOP was higher in older individuals with low levels of leptin and higher levels of chemerin. In addition, BMI was somewhat lower with low levels of leptin and adiponectin.

Systematic review registration

https://www.crd.york.ac.uk/prospero/, identifier CRD42022356469.

SUBMITTER: Wang J

PROVIDER: S-EPMC10415163 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

The association between serum adipokines levels with senile osteoporosis: a systematic review and meta-analysis.

Wang Jiangna J Liu Shiwei S Zhao Yuxiang Y Naqvi Syed Shah Zaman Haider SSZH Duan Ruixue R

Frontiers in endocrinology 20230727

<h4>Objective</h4>The clinical correlation between adipokines levels in the blood and the incidence of senile osteoporosis (SOP) has not been clearly studied. We conducted this meta-analysis to elucidate the relationship between three common adipokines levels (leptin, adiponectin, and chemerin) and the incidence of SOP.<h4>Methods</h4>We searched databases such as CNKI, CBM, VIP, Wanfang, PubMed, Web of Science, Embase, and the Cochrane Library to collect articles published since the establishme ...[more]

PMID: 37576959

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Dataset Information

The association between serum adipokines levels with senile osteoporosis: a systematic review and meta-analysis.

Objective

Methods

Results

Conclusions

Systematic review registration

Publications

The association between serum adipokines levels with senile osteoporosis: a systematic review and meta-analysis.

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