Ontology highlight
ABSTRACT:
SUBMITTER: Trirocco R
PROVIDER: S-EPMC10425336 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Trirocco Rita R Pasqua Martina M Tramonti Angela A Colonna Bianca B Paiardini Alessandro A Prosseda Gianni G
Scientific reports 20230814 1
Shigella, the aetiological agent of human bacillary dysentery, controls the expression of its virulence determinants through an environmentally stimulated cascade of transcriptional activators. VirF is the leading activator and is essential for proper virulence expression. In this work, we report on in vitro and in vivo experiments showing that two autoinducers of the DSF family, XcDSF and BDSF interact with the jelly roll module of VirF causing its inhibition and affecting the expression of the ...[more]