Ontology highlight
ABSTRACT:
SUBMITTER: Emanuele AA
PROVIDER: S-EPMC4050983 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Emanuele Anthony A AA Adams Nancy E NE Chen Yi-Chen YC Maurelli Anthony T AT Garcia George A GA
The Journal of antibiotics 20140219 5
VirF is an AraC-type transcriptional regulator responsible for activating the transcription of virulence genes required for the intracellular invasion and cell-to-cell spread of Shigella flexneri. Gene disruption studies have validated VirF as a potential target for an anti-virulence therapy to treat shigellosis by determining that VirF is necessary for virulence, but not required for bacterial viability. Using a bacteria-based, β-galactosidase reporter assay we completed a high-throughput scree ...[more]