Ontology highlight
ABSTRACT:
SUBMITTER: Johnson ECB
PROVIDER: S-EPMC10427428 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Johnson Erik C B ECB Bian Shijia S Haque Rafi U RU Carter E Kathleen EK Watson Caroline M CM Gordon Brian A BA Ping Lingyan L Duong Duc M DM Epstein Michael P MP McDade Eric E Barthélemy Nicolas R NR Karch Celeste M CM Xiong Chengjie C Cruchaga Carlos C Perrin Richard J RJ Wingo Aliza P AP Wingo Thomas S TS Chhatwal Jasmeer P JP Day Gregory S GS Noble James M JM Berman Sarah B SB Martins Ralph R Graff-Radford Neill R NR Schofield Peter R PR Ikeuchi Takeshi T Mori Hiroshi H Levin Johannes J Farlow Martin M Lah James J JJ Haass Christian C Jucker Mathias M Morris John C JC Benzinger Tammie L S TLS Roberts Blaine R BR Bateman Randall J RJ Fagan Anne M AM Seyfried Nicholas T NT Levey Allan I AI
Nature medicine 20230807 8
Alzheimer's disease (AD) pathology develops many years before the onset of cognitive symptoms. Two pathological processes-aggregation of the amyloid-β (Aβ) peptide into plaques and the microtubule protein tau into neurofibrillary tangles (NFTs)-are hallmarks of the disease. However, other pathological brain processes are thought to be key disease mediators of Aβ plaque and NFT pathology. How these additional pathologies evolve over the course of the disease is currently unknown. Here we show tha ...[more]