Ontology highlight
ABSTRACT:
SUBMITTER: Schindler SE
PROVIDER: S-EPMC6511459 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Schindler Suzanne E SE Li Yan Y Todd Kaitlin W KW Herries Elizabeth M EM Henson Rachel L RL Gray Julia D JD Wang Guoqiao G Graham Danielle L DL Shaw Leslie M LM Trojanowski John Q JQ Hassenstab Jason J JJ Benzinger Tammie L S TLS Cruchaga Carlos C Jucker Mathias M Levin Johannes J Chhatwal Jasmeer P JP Noble James M JM Ringman John M JM Graff-Radford Neill R NR Holtzman David M DM Ladenson Jack H JH Morris John C JC Bateman Randall J RJ Xiong Chengjie C Fagan Anne M AM
Alzheimer's & dementia : the journal of the Alzheimer's Association 20190304 5
<h4>Introduction</h4>Four less well-studied but promising "emerging" cerebrospinal fluid (CSF) biomarkers are elevated in late-onset Alzheimer disease (AD): neurogranin, synaptosomal-associated protein-25 (SNAP-25), visinin-like protein 1 (VILIP-1), and chitinase-3-like protein 1 (YKL-40).<h4>Methods</h4>CSF neurogranin, SNAP-25, VILIP-1, and YKL-40 were measured in families carrying autosomal-dominant AD mutations.<h4>Results</h4>The four emerging CSF biomarkers were significantly elevated in t ...[more]