Ontology highlight
ABSTRACT:
SUBMITTER: Horvath S
PROVIDER: S-EPMC10441355 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Horvath Steve S Singh Kavita K Raj Ken K Khairnar Shraddha S Sanghavi Akshay A Shrivastava Agnivesh A Zoller Joseph A JA Li Caesar Z CZ Herenu Claudia B CB Canatelli-Mallat Martina M Lehmann Marianne M Habazin Siniša S Novokmet Mislav M Vučković Frano F Woods Leah C Solberg LCS Martinez Angel Garcia AG Wang Tengfei T Chiavellini Priscila P Levine Andrew J AJ Chen Hao H Brooke Robert T RT Gordevicius Juozas J Lauc Gordan G Goya Rodolfo G RG Katcher Harold L HL
bioRxiv : the preprint server for biology 20230807
Young blood plasma is known to confer beneficial effects on various organs in mice and rats. However, it was not known whether plasma from young pigs rejuvenates old rat tissues at the epigenetic level; whether it alters the epigenetic clock, which is a highly accurate molecular biomarker of aging. To address this question, we developed and validated six different epigenetic clocks for rat tissues that are based on DNA methylation values derived from n=613 tissue samples. As indicated by their r ...[more]