S-EPMC10445263 - Sex and age-specific interactions of coronary atherosclerotic plaque onset and prognosis from coronary computed tomography. - OmicsDI

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Dataset Information

Sex and age-specific interactions of coronary atherosclerotic plaque onset and prognosis from coronary computed tomography.

ABSTRACT:

Aims

The totality of atherosclerotic plaque derived from coronary computed tomography angiography (CCTA) emerges as a comprehensive measure to assess the intensity of medical treatment that patients need. This study examines the differences in age onset and prognostic significance of atherosclerotic plaque burden between sexes.

Methods and results

From a large multi-center CCTA registry the Leiden CCTA score was calculated in 24 950 individuals. A total of 11 678 women (58.5 ± 12.4 years) and 13 272 men (55.6 ± 12.5 years) were followed for 3.7 years for major adverse cardiovascular events (MACE) (death or myocardial infarction). The age where the median risk score was above zero was 12 years higher in women vs. men (64-68 years vs. 52-56 years, respectively, P < 0.001). The Leiden CCTA risk score was independently associated with MACE: score 6-20: HR 2.29 (1.69-3.10); score > 20: HR 6.71 (4.36-10.32) in women, and score 6-20: HR 1.64 (1.29-2.08); score > 20: HR 2.38 (1.73-3.29) in men. The risk was significantly higher for women within the highest score group (adjusted P-interaction = 0.003). In pre-menopausal women, the risk score was equally predictive and comparable with men. In post-menopausal women, the prognostic value was higher for women [score 6-20: HR 2.21 (1.57-3.11); score > 20: HR 6.11 (3.84-9.70) in women; score 6-20: HR 1.57 (1.19-2.09); score > 20: HR 2.25 (1.58-3.22) in men], with a significant interaction for the highest risk group (adjusted P-interaction = 0.004).

Conclusion

Women developed coronary atherosclerosis approximately 12 years later than men. Post-menopausal women within the highest atherosclerotic burden group were at significantly higher risk for MACE than their male counterparts, which may have implications for the medical treatment intensity.

SUBMITTER: van Rosendael SE

PROVIDER: S-EPMC10445263 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature

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Publications

Sex and age-specific interactions of coronary atherosclerotic plaque onset and prognosis from coronary computed tomography.

van Rosendael Sophie E SE Bax A Maxim AM Lin Fay Y FY Achenbach Stephan S Andreini Daniele D Budoff Matthew J MJ Cademartiri Filippo F Callister Tracy Q TQ Chinnaiyan Kavitha K Chow Benjamin J W BJW Cury Ricardo C RC DeLago Augustin J AJ Feuchtner Gudrun G Hadamitzky Martin M Hausleiter Joerg J Kaufmann Philipp A PA Kim Yong-Jin YJ Leipsic Jonathon A JA Maffei Erica E Marques Hugo H de Araújo Gonçalves Pedro P Pontone Gianluca G Raff Gilbert L GL Rubinshtein Ronen R Villines Todd C TC Chang Hyuk-Jae HJ Berman Daniel S DS Min James K JK Bax Jeroen J JJ Shaw Leslee J LJ van Rosendael Alexander R AR

European heart journal. Cardiovascular Imaging 20230801 9

<h4>Aims</h4>The totality of atherosclerotic plaque derived from coronary computed tomography angiography (CCTA) emerges as a comprehensive measure to assess the intensity of medical treatment that patients need. This study examines the differences in age onset and prognostic significance of atherosclerotic plaque burden between sexes.<h4>Methods and results</h4>From a large multi-center CCTA registry the Leiden CCTA score was calculated in 24 950 individuals. A total of 11 678 women (58.5 ± 12. ...[more]

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