Iodine-enhanced micro-computed tomography of atherosclerotic plaque morphology complements conventional histology.

ABSTRACT:

Background and aims

Visualization of arterial lesions in situ can enhance understanding of atherosclerosis progression and potentially improve experimental therapies. Conventional histology methods for assessing atherosclerotic lesions are robust but are destructive and may prevent further tissue analysis. The objective of the current study was to evaluate a novel, nondestructive method for visualization and characterization of atherosclerotic lesions as an alternative or complementary to routine histology. Thus, we tested the hypothesis that micro-computed tomography (micro-CT) paired with an iodine-based radiopaque stain would effectively characterize atherosclerotic plaques in a manner comparable to routine histology while maintaining sample integrity and providing whole-volume

SUBMITTER: Self TS 

PROVIDER: S-EPMC7655693 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature