Ontology highlight
ABSTRACT:
SUBMITTER: Short AE
PROVIDER: S-EPMC10465543 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Short Andrew E AE Kim Dowan D Milner Prasaad T PT Wilson Corey J CJ
Nature communications 20230829 1
Here we present a technology to facilitate synthetic memory in a living system via repurposing Transcriptional Programming (i.e., our decision-making technology) parts, to regulate (intercept) recombinase function post-translation. We show that interception synthetic memory can facilitate programmable loss-of-function via site-specific deletion, programmable gain-of-function by way of site-specific inversion, and synthetic memory operations with nested Boolean logical operations. We can expand i ...[more]