Ontology highlight
ABSTRACT:
SUBMITTER: Dumas SN
PROVIDER: S-EPMC6909887 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Dumas Sabrina N SN Lamming Dudley W DW
The journals of gerontology. Series A, Biological sciences and medical sciences 20200101 1
Inhibition of mTORC1 (mechanistic Target Of Rapamycin Complex 1) with the pharmaceutical rapamycin prolongs the lifespan and healthspan of model organisms including rodents, with evidence now emerging that rapamycin and its analogs may also have rejuvenative effects in dogs and humans. However, the side effects associated with long-term rapamycin treatment, many of which are due to inhibition of a second mTOR complex, mTORC2, have seemed to preclude the routine use of rapamycin as a therapy for ...[more]