Risk of second primary cancer from proton arc therapy of pediatric brain tumors.
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ABSTRACT:
SUBMITTER: Toussaint L
PROVIDER: S-EPMC10465935 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Publications
Risk of second primary cancer from proton arc therapy of pediatric brain tumors.
Toussaint Laura L Indelicato Daniel J DJ Muren Ludvig P LP Stokkevåg Camilla H CH
Physics and imaging in radiation oncology 20230701
Proton arc therapy (PAT) is currently explored for clinical implementation, despite its associated low-dose bath. This study therefore aimed at evaluating the risk of radiation-induced second primary cancer (SPC) for PAT in pediatric brain tumor patients. Two brain-specific models for SPC induction were applied in five cases to compare volumetric modulated arc therapy (VMAT), intensity modulated proton therapy (IMPT) and PAT surrogate plans. The PAT integral dose was reduced by a median of 29% c ...[more]
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