Ontology highlight
ABSTRACT:
SUBMITTER: Xing J
PROVIDER: S-EPMC10468136 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Xing Jiawei J Gumerov Vadim M VM Zhulin Igor B IB
Science advances 20230830 35
Signal perception is a key function in regulating biological activities and adapting to changing environments. Per-Arnt-Sim (PAS) domains are ubiquitous sensors found in diverse receptors in bacteria, archaea, and eukaryotes, but their origins, distribution across the tree of life, and extent of their functional diversity are not fully characterized. Here, we show that using sequence conservation and structural information, it is possible to propose specific and potential functions for a large p ...[more]