Hospitalization risk among patients with Mpox infection—a propensity score matched analysis
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ABSTRACT: Background:
Monkeypox (Mpox) is a reemerging, neglected viral disease. By May 2023, worldwide Mpox cases surpassed 87,000. Predictive factors for hospitalization with Mpox are lacking. Objective:
We aim to compare clinical characteristics and outcomes in hospitalized and nonhospitalized patients with Mpox infection. Design:
A multicenter retrospective case-control cohort of patients with Mpox infection. Methods:
We performed a propensity score match analysis from a global health network (TrinetX). We compare clinical characteristics and outcomes between hospitalized and nonhospitalized patients with Mpox. Results:
Of 1477 patients, 6% were hospitalized, 52% required an ED visit, and 29% received treatment at urgent care. After propensity score matching, 80 patients remained in each group. Hospitalizations were more common among Black persons (51% versus 33%, p = 0.01), people with HIV (50% versus 20%, p < 0.0001), and those with proctitis (44% versus 12.5%, p < 0.001). Conclusion:
Independent predictive factors of hospitalization in our cohort for Mpox included people who are Black with a diagnosis of HIV, severe proctitis, pain requiring opioids, and elevated lactate dehydrogenase. Greater recognition of factors associated with increased risk of Mpox severity and hospitalization is paramount.
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PROVIDER: S-EPMC10469242 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
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