Ontology highlight
ABSTRACT:
SUBMITTER: Hu Y
PROVIDER: S-EPMC10470402 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Hu Yan Y Hou Yan Y Zhou Shijie S Wang Yingzhi Y Shen Congcong C Mu Li L Su Dan D Zhang Rundong R
iScience 20230812 9
The spliceosomal snRNP cores, each comprised of a snRNA and a seven-membered Sm ring (D1/D2/F/E/G/D3/B), are assembled by twelve chaperoning proteins in human. However, only six assembly-assisting proteins, ICln and the SMN complex (SMN/Gemin2/Gemin6-8), have been found in <i>Schizosaccharomyces pombe</i> (Sp). Here, we used recombinant proteins to reconstitute the chaperone machinery and investigated the roles of these proteins systematically. We found that, like the human system, the assembly ...[more]