Mitoquinone Mesylate and Mitochondrial DNA in End Organs in Humanized Mouse Model of Chronic Treated Human Immunodeficiency Virus Infection.
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SUBMITTER: Song S
PROVIDER: S-EPMC10474938 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
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Mitoquinone Mesylate and Mitochondrial DNA in End Organs in Humanized Mouse Model of Chronic Treated Human Immunodeficiency Virus Infection.
Song Sihyeong S Satta Sandro S Sharma Madhav B MB Hugo Cristelle C Kossyvakis Athanassios A Sen Roy Shubhendu S Kelesidis Theodoros T
The Journal of infectious diseases 20230601 1
No treatment exists for mitochondrial dysfunction, a contributor to end-organ disease in human immunodeficiency virus (HIV). The mitochondrial antioxidant mitoquinone mesylate (MitoQ) attenuates mitochondrial dysfunction in preclinical mouse models of various diseases but has not been used in HIV. We used a humanized murine model of chronic HIV infection and polymerase chain reaction to show that HIV-1-infected mice treated with antiretroviral therapy and MitoQ for 90 days had higher ratios of h ...[more]
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