Ontology highlight
ABSTRACT:
SUBMITTER: Samal J
PROVIDER: S-EPMC6237217 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Samal Jasmine J Kelly Samantha S Na-Shatal Ali A Elhakiem Abdallah A Das Antu A Ding Ming M Sanyal Anwesha A Gupta Phalguni P Melody Kevin K Roland Brad B Ahmed Watfa W Zakir Aala A Bility Moses M
JCI insight 20180920 18
A major pathogenic feature associated with HIV infection is lymphoid fibrosis, which persists during antiretroviral therapy (ART). Lymphoid tissues play critical roles in the generation of antigen-specific immune response, and fibrosis disrupts the stromal network of lymphoid tissues, resulting in impaired immune cell trafficking and function, as well as immunodeficiency. Developing an animal model for investigating the impact of HIV infection-induced lymphoid tissue fibrosis on immunodeficiency ...[more]