Lactate metabolism in neurodegenerative diseases.
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ABSTRACT:
SUBMITTER: Yang C
PROVIDER: S-EPMC10479854 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
Publications
Lactate metabolism in neurodegenerative diseases.
Yang Chaoguang C Pan Rui-Yuan RY Guan Fangxia F Yuan Zengqiang Z
Neural regeneration research 20240101 1
Lactate, a byproduct of glycolysis, was thought to be a metabolic waste until the discovery of the Warburg effect. Lactate not only functions as a metabolic substrate to provide energy but can also function as a signaling molecule to modulate cellular functions under pathophysiological conditions. The Astrocyte-Neuron Lactate Shuttle has clarified that lactate plays a pivotal role in the central nervous system. Moreover, protein lactylation highlights the novel role of lactate in regulating tran ...[more]
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