Ontology highlight
ABSTRACT:
SUBMITTER: Norwitz NG
PROVIDER: S-EPMC7418707 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Norwitz Nicholas G NG Jaramillo Javier Gilbert JG Clarke Kieran K Soto Adrian A
International review of neurobiology 20200811
Alzheimer's disease (AD) and Parkinson's disease (PD) are, respectively, the most prevalent and fastest growing neurodegenerative diseases worldwide. The former is primarily characterized by memory loss and the latter by the motor symptoms of tremor and bradykinesia. Both AD and PD are progressive diseases that share several key underlying mitochondrial, inflammatory, and other metabolic pathologies. This review will detail how these pathologies intersect with ketone body metabolism and signalin ...[more]