Ontology highlight
ABSTRACT:
SUBMITTER: Saddic L
PROVIDER: S-EPMC10487461 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Saddic Louis L Escopete Sean S Zilberberg Lior L Kalsow Shannon S Gupta Divya D Eghbali Mansoureh M Parker Sarah S
International journal of molecular sciences 20230901 17
Marfan syndrome causes a hereditary form of thoracic aortic aneurysms with worse outcomes in male compared to female patients. In this study, we examine the effects of 17 β-estradiol on aortic dilation and rupture in a Marfan mouse model. Marfan male mice were administered 17 β-estradiol, and the growth in the aortic root, along with the risk of aortic rupture, was measured. Transcriptomic profiling was used to identify enriched pathways from 17 β-estradiol treatments. Aortic smooth muscle cells ...[more]