Unknown

Dataset Information

0

17 β-Estradiol Impedes Aortic Root Dilation and Rupture in Male Marfan Mice.


ABSTRACT: Marfan syndrome causes a hereditary form of thoracic aortic aneurysms with worse outcomes in male compared to female patients. In this study, we examine the effects of 17 β-estradiol on aortic dilation and rupture in a Marfan mouse model. Marfan male mice were administered 17 β-estradiol, and the growth in the aortic root, along with the risk of aortic rupture, was measured. Transcriptomic profiling was used to identify enriched pathways from 17 β-estradiol treatments. Aortic smooth muscle cells were then treated with cytokines to validate functional mechanisms. We show that 17 β-estradiol decreased the size and rate of aortic root dilation and improved survival from rupture. The Marfan transcriptome was enriched in inflammatory genes, and the addition of 17 β-estradiol modulated a set of genes that function through TNFα mediated NF-κB signaling. In addition, 17 β-estradiol suppressed the induction of these TNFα induced genes in aortic smooth muscle cells in vitro in an NF-κB dependent manner, and 17 β-estradiol decreased the formation of adventitial inflammatory foci in aortic roots in vivo. In conclusion, 17 β-estradiol protects against the dilation and rupture of aortic roots in Marfan male mice through the inhibition of TNFα-NF-κB signaling.

SUBMITTER: Saddic L 

PROVIDER: S-EPMC10487461 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

altmetric image

Publications

17 β-Estradiol Impedes Aortic Root Dilation and Rupture in Male Marfan Mice.

Saddic Louis L   Escopete Sean S   Zilberberg Lior L   Kalsow Shannon S   Gupta Divya D   Eghbali Mansoureh M   Parker Sarah S  

International journal of molecular sciences 20230901 17


Marfan syndrome causes a hereditary form of thoracic aortic aneurysms with worse outcomes in male compared to female patients. In this study, we examine the effects of 17 β-estradiol on aortic dilation and rupture in a Marfan mouse model. Marfan male mice were administered 17 β-estradiol, and the growth in the aortic root, along with the risk of aortic rupture, was measured. Transcriptomic profiling was used to identify enriched pathways from 17 β-estradiol treatments. Aortic smooth muscle cells  ...[more]

Similar Datasets

| S-EPMC10197695 | biostudies-literature
2024-02-14 | PXD037853 | Pride
| S-EPMC6150800 | biostudies-literature
| S-EPMC9851465 | biostudies-literature
| S-EPMC7525511 | biostudies-literature
| S-EPMC5786652 | biostudies-literature
| S-EPMC8583889 | biostudies-literature
| S-EPMC4131445 | biostudies-literature
| S-EPMC5721101 | biostudies-literature
| S-EPMC5132207 | biostudies-literature