Detection of diagnostic and prognostic methylation-based signatures in liquid biopsy specimens from patients with meningiomas.
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ABSTRACT:
SUBMITTER: Herrgott GA
PROVIDER: S-EPMC10499807 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Publications
Detection of diagnostic and prognostic methylation-based signatures in liquid biopsy specimens from patients with meningiomas.
Herrgott Grayson A GA Snyder James M JM She Ruicong R Malta Tathiane M TM Sabedot Thais S TS Lee Ian Y IY Pawloski Jacob J Podolsky-Gondim Guilherme G GG Asmaro Karam P KP Zhang Jiaqi J Cannella Cara E CE Nelson Kevin K Thomas Bartow B deCarvalho Ana C AC Hasselbach Laura A LA Tundo Kelly M KM Newaz Rehnuma R Transou Andrea A Morosini Natalia N Francisco Victor V Poisson Laila M LM Chitale Dhananjay D Mukherjee Abir A Mosella Maritza S MS Robin Adam M AM Walbert Tobias T Rosenblum Mark M Mikkelsen Tom T Kalkanis Steven S Tirapelli Daniela P C DPC Weisenberger Daniel J DJ Carlotti Carlos G CG Rock Jack J Castro Ana Valeria AV Noushmehr Houtan H
Nature communications 20230913 1
Recurrence of meningiomas is unpredictable by current invasive methods based on surgically removed specimens. Identification of patients likely to recur using noninvasive approaches could inform treatment strategy, whether intervention or monitoring. In this study, we analyze the DNA methylation levels in blood (serum and plasma) and tissue samples from 155 meningioma patients, compared to other central nervous system tumor and non-tumor entities. We discover DNA methylation markers unique to me ...[more]
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