Ontology highlight
ABSTRACT:
SUBMITTER: Lopes JR
PROVIDER: S-EPMC10500187 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Lopes Juliana R JR Zhang Xiaoming X Mayrink Julia J Tatematsu Bruna K BK Guo Lydia L LeServe Danielle S DS Abou-El-Hassan Hadi H Rong Felipe F Dalton Maria J MJ Oliveira Marilia G MG Lanser Toby B TB Liu Lei L Butovsky Oleg O Rezende Rafael M RM Weiner Howard L HL
Proceedings of the National Academy of Sciences of the United States of America 20230905 37
Emerging evidence suggests that dysregulation of neuroinflammation, particularly that orchestrated by microglia, plays a significant role in the pathogenesis of Alzheimer's disease (AD). Danger signals including dead neurons, dystrophic axons, phosphorylated tau, and amyloid plaques alter the functional phenotype of microglia from a homeostatic (M0) to a neurodegenerative or disease-associated phenotype, which in turn drives neuroinflammation and promotes disease. Thus, therapies that target mic ...[more]