Ontology highlight
ABSTRACT:
SUBMITTER: Yamada S
PROVIDER: S-EPMC6039309 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Yamada Shinji S Itai Shunsuke S Kaneko Mika K MK Konnai Satoru S Kato Yukinari Y
Biochemistry and biophysics reports 20180709
Mouse podoplanin (mPDPN) is a type I transmembrane sialoglycoprotein, which is expressed on lymphatic endothelial cells, podocytes of the kidney, and type I alveolar cells of the lung. mPDPN is known as a platelet aggregation-inducing factor and possesses four platelet aggregation-stimulating (PLAG) domains: PLAG1, PLAG2, and PLAG3 in the N-terminus and PLAG4 in the middle of the mPDPN protein. mPDPN overexpression in cancers has been reportedly associated with hematogenous metastasis through in ...[more]