Ontology highlight
ABSTRACT:
SUBMITTER: Xu Z
PROVIDER: S-EPMC10511561 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Xu Zhichun Z Feng Jianrong J Yu Daqi D Huo Yunjing Y Ma Xiaohui X Lam Wai Hei WH Liu Zheng Z Li Xiang David XD Ishibashi Toyotaka T Dang Shangyu S Zhai Yuanliang Y
Nature communications 20230920 1
The replisome that replicates the eukaryotic genome consists of at least three engines: the Cdc45-MCM-GINS (CMG) helicase that separates duplex DNA at the replication fork and two DNA polymerases, one on each strand, that replicate the unwound DNA. Here, we determined a series of cryo-electron microscopy structures of a yeast replisome comprising CMG, leading-strand polymerase Polε and three accessory factors on a forked DNA. In these structures, Polε engages or disengages with the motor domains ...[more]