Ontology highlight
ABSTRACT:
SUBMITTER: Gruchot J
PROVIDER: S-EPMC10515160 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Gruchot Joel J Lewen Isabel I Dietrich Michael M Reiche Laura L Sindi Mustafa M Hecker Christina C Herrero Felisa F Charvet Benjamin B Weber-Stadlbauer Ulrike U Hartung Hans-Peter HP Albrecht Philipp P Perron Hervé H Meyer Urs U Küry Patrick P
Proceedings of the National Academy of Sciences of the United States of America 20230911 38
The human endogenous retrovirus type W (HERV-W) has been identified and repeatedly confirmed as human-specific pathogenic entity affecting many cell types in multiple sclerosis (MS). Our recent contributions revealed the encoded envelope (ENV) protein to disturb myelin repair by interfering with oligodendroglial precursor differentiation and by polarizing microglial cells toward an axon-damage phenotype. Indirect proof of ENV's antiregenerative and degenerative activities has been gathered recen ...[more]