Dataset Information

Age- and disease-dependent HERV-W envelope allelic variation in brain: association with neuroimmune gene expression.

ABSTRACT:

Background

The glycoprotein, Syncytin-1, is encoded by a human endogenous retrovirus (HERV)-W env gene and is capable of inducing neuroinflammation. The specific allele(s) responsible for Syncytin-1 expression in the brain is uncertain. Herein, HERV-W env diversity together with Syncytin-1 abundance and host immune gene profiles were examined in the nervous system using a multiplatform approach.

Results

HERV-W env sequences were encoded by multiple chromosomal encoding loci in primary human neurons compared with less chromosomal diversity in astrocytes and microglia (p<0.05). HERV-W env RNA sequences cloned from brains of patients with systemic or neurologic diseases were principally derived from chromosomal locus 7q21.2. Within the same specimens, HERV-W env transcript levels were correlated with the expression of multiple proinflammatory genes (p<0.05). Deep sequencing of brain transcriptomes disclosed the env transcripts to be the most abundant HERV-W transcripts, showing greater expression in fetal compared with healthy adult brain specimens. Syncytin-1's expression in healthy brain specimens was derived from multiple encoding loci and linked to distinct immune and developmental gene profiles.

Conclusions

Syncytin-1 expression in the brain during disease was associated with neuroinflammation and was principally encoded by a full length provirus. The present studies also highlighted the diversity in HERV gene expression within the brain and reinforce the potential contributions of HERV expression to neuroinflammatory diseases.

SUBMITTER: Bhat RK

PROVIDER: S-EPMC3084769 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature

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Publications

Age- and disease-dependent HERV-W envelope allelic variation in brain: association with neuroimmune gene expression.

Bhat Rakesh K RK Ellestad Kristofor K KK Wheatley B Matt BM Warren Rene R Holt Robert A RA Power Christopher C

PloS one 20110429 4

<h4>Background</h4>The glycoprotein, Syncytin-1, is encoded by a human endogenous retrovirus (HERV)-W env gene and is capable of inducing neuroinflammation. The specific allele(s) responsible for Syncytin-1 expression in the brain is uncertain. Herein, HERV-W env diversity together with Syncytin-1 abundance and host immune gene profiles were examined in the nervous system using a multiplatform approach.<h4>Results</h4>HERV-W env sequences were encoded by multiple chromosomal encoding loci in pri ...[more]

PMID: 21559469

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Dataset Information

Age- and disease-dependent HERV-W envelope allelic variation in brain: association with neuroimmune gene expression.

Background

Results

Conclusions

Publications

Age- and disease-dependent HERV-W envelope allelic variation in brain: association with neuroimmune gene expression.

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