Ontology highlight
ABSTRACT:
SUBMITTER: Sattiraju A
PROVIDER: S-EPMC10527169 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Sattiraju Anirudh A Kang Sangjo S Giotti Bruno B Chen Zhihong Z Marallano Valerie J VJ Brusco Concetta C Ramakrishnan Aarthi A Shen Li L Tsankov Alexander M AM Hambardzumyan Dolores D Friedel Roland H RH Zou Hongyan H
Immunity 20230713 8
Glioblastoma (GBM), a highly lethal brain cancer, is notorious for immunosuppression, but the mechanisms remain unclear. Here, we documented a temporospatial patterning of tumor-associated myeloid cells (TAMs) corresponding to vascular changes during GBM progression. As tumor vessels transitioned from the initial dense regular network to later scant and engorged vasculature, TAMs shifted away from perivascular regions and trafficked to vascular-poor areas. This process was heavily influenced by ...[more]