Ontology highlight
ABSTRACT:
SUBMITTER: Ganapathy AS
PROVIDER: S-EPMC10528852 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Ganapathy Ashwinkumar Subramenium AS Saha Kushal K Wang Alexandra A Arumugam Priya P Dharmaprakash Viszwapriya V Yochum Gregory G Koltun Walter W Nighot Meghali M Perdew Gary G Thompson Todd A TA Ma Thomas T Nighot Prashant P
Cell reports 20230630 7
Defects in intestinal epithelial tight junctions (TJs) allow paracellular permeation of noxious luminal antigens and are important pathogenic factors in inflammatory bowel disease (IBD). We show that alpha-tocopherylquinone (TQ), a quinone-structured oxidation product of vitamin E, consistently enhances the intestinal TJ barrier by increasing barrier-forming claudin-3 (CLDN3) and reducing channel-forming CLDN2 in Caco-2 cell monolayers (in vitro), mouse models (in vivo), and surgically resected ...[more]