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Claudins and the modulation of tight junction permeability.

ABSTRACT: Claudins are tight junction membrane proteins that are expressed in epithelia and endothelia and form paracellular barriers and pores that determine tight junction permeability. This review summarizes our current knowledge of this large protein family and discusses recent advances in our understanding of their structure and physiological functions.

SUBMITTER: Gunzel D

PROVIDER: S-EPMC3768107 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

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Claudins and the modulation of tight junction permeability.

Günzel Dorothee D Yu Alan S L AS

Physiological reviews 20130401 2

Claudins are tight junction membrane proteins that are expressed in epithelia and endothelia and form paracellular barriers and pores that determine tight junction permeability. This review summarizes our current knowledge of this large protein family and discusses recent advances in our understanding of their structure and physiological functions. ...[more]

PMID: 23589827

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Tight Junction Claudins-associated vascular heterogeneity determines organotypic metastasis

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Interleukin-6 modulation of intestinal epithelial tight junction permeability is mediated by JNK pathway activation of claudin-2 gene.

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The Tight Junction Protein Claudin-2 Controls Mucosal Permeability, Immune Tolerance and Colitis in Mice

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2013-09-15 | E-GEOD-46006 | biostudies-arrayexpress

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