Ontology highlight
ABSTRACT:
SUBMITTER: Chitraju C
PROVIDER: S-EPMC10545428 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Chitraju Chandramohan C Fischer Alexander W AW Ambaw Yohannes A YA Wang Kun K Yuan Bo B Hui Sheng S Walther Tobias C TC Farese Robert V RV
eLife 20231002
Triglycerides (TGs) in adipocytes provide the major stores of metabolic energy in the body. Optimal amounts of TG stores are desirable as insufficient capacity to store TG, as in lipodystrophy, or exceeding the capacity for storage, as in obesity, results in metabolic disease. We hypothesized that mice lacking TG storage in adipocytes would result in excess TG storage in cell types other than adipocytes and severe lipotoxicity accompanied by metabolic disease. To test this hypothesis, we selecti ...[more]