Ontology highlight
ABSTRACT:
SUBMITTER: Yu IC
PROVIDER: S-EPMC2329275 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Yu I-Chen IC Lin Hung-Yun HY Liu Ning-Chun NC Wang Ruey-Shen RS Sparks Janet D JD Yeh Shuyuan S Chang Chawnshang C
Endocrinology 20080214 5
Insulin resistance occurs through an inadequate response to insulin by insulin target organs such as liver, muscle, and adipose tissue with consequent insufficient glucose uptake. In previous studies we demonstrated that whole body androgen receptor (AR) knockout (AR(-/y)) mice develop obesity and exhibit insulin and leptin resistance at advanced age. By examining adipose tissue-specific AR knockout (A-AR(-/y)) mice, we found A-AR(-/y) mice were hyperleptinemic but showed no leptin resistance, a ...[more]