Ontology highlight
ABSTRACT:
SUBMITTER: Giovanelli R
PROVIDER: S-EPMC10546374 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Giovanelli Riccardo R Lombardi Lorenzo L Pedrazzani Riccardo R Monari Magda M Reis Marta Castiñeira MC López Carlos Silva CS Bertuzzi Giulio G Bandini Marco M
Organic letters 20230905 38
A carbonylation-carboxylation synthetic sequence, via double CO<sub>2</sub> fixation, is described. The productive merger of a Ni-catalyzed cross-electrophile coupling manifold, with the use of AlCl<sub>3</sub>, triggered a cascade reaction with the formation of three consecutive C-C bonds in a single operation. This strategy traces an unprecedented synthetic route to ketones under Lewis acid assisted carbon dioxide valorization. Computational insights revealed a unique double function of AlCl<s ...[more]