Unknown

Dataset Information

0

Nickel Catalyzed Carbonylation/Carboxylation Sequence via Double CO2 Incorporation.


ABSTRACT: A carbonylation-carboxylation synthetic sequence, via double CO2 fixation, is described. The productive merger of a Ni-catalyzed cross-electrophile coupling manifold, with the use of AlCl3, triggered a cascade reaction with the formation of three consecutive C-C bonds in a single operation. This strategy traces an unprecedented synthetic route to ketones under Lewis acid assisted carbon dioxide valorization. Computational insights revealed a unique double function of AlCl3, and labeling (13CO2) experiments validate the genuine incorporation of CO2 in both functional groups.

SUBMITTER: Giovanelli R 

PROVIDER: S-EPMC10546374 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

altmetric image

Publications

Nickel Catalyzed Carbonylation/Carboxylation Sequence via Double CO<sub>2</sub> Incorporation.

Giovanelli Riccardo R   Lombardi Lorenzo L   Pedrazzani Riccardo R   Monari Magda M   Reis Marta Castiñeira MC   López Carlos Silva CS   Bertuzzi Giulio G   Bandini Marco M  

Organic letters 20230905 38


A carbonylation-carboxylation synthetic sequence, via double CO<sub>2</sub> fixation, is described. The productive merger of a Ni-catalyzed cross-electrophile coupling manifold, with the use of AlCl<sub>3</sub>, triggered a cascade reaction with the formation of three consecutive C-C bonds in a single operation. This strategy traces an unprecedented synthetic route to ketones under Lewis acid assisted carbon dioxide valorization. Computational insights revealed a unique double function of AlCl<s  ...[more]

Similar Datasets

| S-EPMC8648755 | biostudies-literature
| S-EPMC5982211 | biostudies-literature
| S-EPMC2928647 | biostudies-literature
| S-EPMC7496797 | biostudies-literature
| S-EPMC8175691 | biostudies-literature
| S-EPMC9897662 | biostudies-literature
| S-EPMC10337029 | biostudies-literature
| S-EPMC6013789 | biostudies-literature
| S-EPMC9948557 | biostudies-literature
| S-EPMC4878509 | biostudies-literature