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Palladium-catalyzed incorporation of atmospheric CO₂: efficient synthesis of functionalized oxazolidinones.

ABSTRACT: Methods to incorporate atmospheric CO₂ into organic molecules are on demand. Here we present two Pd-catalyzed multicomponent reactions that provide functionalized oxazolidinones from propargylamines, aryl halides and CO₂ as starting materials. These transformations, devoid of high CO₂ pressures, represent a streamlined stereocontrolled synthesis of previously inaccessible versions of these useful heterocycles in an atom-economic manner, as up to four new single bonds are formed in a single synthetic operation.

SUBMITTER: Garcia-Dominguez P

PROVIDER: S-EPMC6013789 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Palladium-catalyzed incorporation of atmospheric CO2: efficient synthesis of functionalized oxazolidinones.

García-Domínguez Patricia P Fehr Lorenz L Rusconi Giulia G Nevado Cristina C

Chemical science 20160310 6

Methods to incorporate atmospheric CO2 into organic molecules are on demand. Here we present two Pd-catalyzed multicomponent reactions that provide functionalized oxazolidinones from propargylamines, aryl halides and CO2 as starting materials. These transformations, devoid of high CO2 pressures, represent a streamlined stereocontrolled synthesis of previously inaccessible versions of these useful heterocycles in an atom-economic manner, as up to four new single b ...[more]

PMID: 30155036

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