Toward Single Bacterium Proteomics.
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ABSTRACT:
SUBMITTER: Vegvari A
PROVIDER: S-EPMC10557376 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Publications
Toward Single Bacterium Proteomics.
Végvári Ákos Á Zhang Xuepei X Zubarev Roman A RA
Journal of the American Society for Mass Spectrometry 20230915 10
Bacteria are orders of magnitude smaller than mammalian cells, and while single cell proteomics (SCP) currently detects and quantifies several thousands of proteins per mammalian cell, it is not clear whether conventional SCP methods will be suitable for bacteria. Here we report on the first successful attempt to detect proteins from individual <i>Escherichia coli</i> bacteria, with validation of our findings by comparison with two bacteria samples and bulk proteomics data. Data are available vi ...[more]
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