Ontology highlight
ABSTRACT:
SUBMITTER: Necarsulmer JC
PROVIDER: S-EPMC10567115 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Necarsulmer Julie C JC Simon Jeremy M JM Evangelista Baggio A BA Chen Youjun Y Tian Xu X Nafees Sara S Marquez Ariana B AB Jiang Huijun H Wang Ping P Ajit Deepa D Nikolova Viktoriya D VD Harper Kathryn M KM Ezzell J Ashley JA Lin Feng-Chang FC Beltran Adriana S AS Moy Sheryl S SS Cohen Todd J TJ
eLife 20231011
TDP-43 proteinopathies including frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are neurodegenerative disorders characterized by aggregation and mislocalization of the nucleic acid-binding protein TDP-43 and subsequent neuronal dysfunction. Here, we developed endogenous models of sporadic TDP-43 proteinopathy based on the principle that disease-associated TDP-43 acetylation at lysine 145 (K145) alters TDP-43 conformation, impairs RNA-binding capacity, and induce ...[more]