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New trimethoprim-resistant dihydrofolate reductase cassette, dfrXV, inserted in a class 1 integron.


ABSTRACT: The nucleotide sequence of a plasmid-borne trimethoprim resistance gene from a commensal fecal Escherichia coli isolate revealed a new dihydrofolate reductase gene, dfrXV, which occurred as a gene cassette integrated in a site-specific manner in a class 1 integron. The new gene shows 84% nucleotide identity and the predicted protein shows 90% amino acid identity with dfrI and DHFR type I, respectively. Genes for spectinomycin resistance, aadA1 [ant (3")-Ia], and sulfonamide resistance, sulI, were located downstream of dfrXV in a manner identical to that in pLMO229.

SUBMITTER: Adrian PV 

PROVIDER: S-EPMC105785 | biostudies-literature | 1998 Sep

REPOSITORIES: biostudies-literature

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New trimethoprim-resistant dihydrofolate reductase cassette, dfrXV, inserted in a class 1 integron.

Adrian P V PV   DU Plessis M M   Klugman K P KP   Amyes S G SG  

Antimicrobial agents and chemotherapy 19980901 9


The nucleotide sequence of a plasmid-borne trimethoprim resistance gene from a commensal fecal Escherichia coli isolate revealed a new dihydrofolate reductase gene, dfrXV, which occurred as a gene cassette integrated in a site-specific manner in a class 1 integron. The new gene shows 84% nucleotide identity and the predicted protein shows 90% amino acid identity with dfrI and DHFR type I, respectively. Genes for spectinomycin resistance, aadA1 [ant (3")-Ia], and sulfonamide resistance, sulI, wer  ...[more]

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