Rapid emergence of high-level resistance to quinolones in Campylobacter jejuni associated with mutational changes in gyrA and parC.
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ABSTRACT:
SUBMITTER: Gibreel A
PROVIDER: S-EPMC106034 | biostudies-literature | 1998 Dec
REPOSITORIES: biostudies-literature
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Rapid emergence of high-level resistance to quinolones in Campylobacter jejuni associated with mutational changes in gyrA and parC.
Gibreel A A Sjögren E E Kaijser B B Wretlind B B Sköld O O
Antimicrobial agents and chemotherapy 19981201 12
Quinolone resistance in clinical isolates of Campylobacter jejuni in Sweden increased more than 20-fold at the beginning of the 1990s. Resistance to 125 microgram of ciprofloxacin per ml in clinical isolates was associated with chromosomal mutations in C. jejuni leading to a Thr-86-Ile substitution in the gyrA product and a Arg-139-Gln substitution in the parC product. ...[more]
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