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Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan.

ABSTRACT: The mechanisms contributing to age-related deterioration of the female reproductive system are complex, however aberrant protein homeostasis is a major contributor. We elucidated exceptionally stable proteins, structures, and macromolecules that persist in mammalian ovaries and gametes across the reproductive lifespan. Ovaries exhibit localized structural and cell-type specific enrichment of stable macromolecules in both the follicular and extrafollicular environments. Moreover, ovaries and oocytes both harbor a panel of exceptionally long-lived proteins, including cytoskeletal, mitochondrial, and oocyte-derived proteins. The exceptional persistence of these long-lived molecules suggest a critical role in lifelong maintenance and age-dependent deterioration of reproductive tissues.

SUBMITTER: Bomba-Warczak EK

PROVIDER: S-EPMC10614913 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature

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Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan.

Bomba-Warczak Ewa K EK Velez Karen M KM Zhou Luhan T LT Guillermier Christelle C Edassery Seby S Steinhauser Matthew L ML Savas Jeffrey N JN Elizabeth Duncan Francesca F

bioRxiv : the preprint server for biology 20240705

The mechanisms contributing to age-related deterioration of the female reproductive system are complex, but aberrant protein homeostasis is a major contributor. We elucidated the exceptionally stable proteins, structures, and macromolecules that persist in mammalian ovaries and gametes across the reproductive lifespan. Ovaries exhibit localized structural and cell-type specific enrichment of stable macromolecules in both the follicular and extrafollicular environments. Moreover, both ovaries and ...[more]

PMID: 37905022

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Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan.

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