Ontology highlight
ABSTRACT:
SUBMITTER: Hsu J
PROVIDER: S-EPMC10616809 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Hsu Jingmei J Van Besien Koen K Glesby Marshall J MJ Pahwa Savita S Coletti Anne A Warshaw Meredith G MG Petz Larry L Moore Theodore B TB Chen Ya Hui YH Pallikkuth Suresh S Dhummakupt Adit A Cortado Ruth R Golner Amanda A Bone Frederic F Baldo Maria M Riches Marcie M Mellors John W JW Tobin Nicole H NH Browning Renee R Persaud Deborah D Bryson Yvonne Y
Cell 20230301 6
Previously, two men were cured of HIV-1 through CCR5Δ32 homozygous (CCR5Δ32/Δ32) allogeneic adult stem cell transplant. We report the first remission and possible HIV-1 cure in a mixed-race woman who received a CCR5Δ32/Δ32 haplo-cord transplant (cord blood cells combined with haploidentical stem cells from an adult) to treat acute myeloid leukemia (AML). Peripheral blood chimerism was 100% CCR5Δ32/Δ32 cord blood by week 14 post-transplant and persisted through 4.8 years of follow-up. Immune reco ...[more]